BIOME Core: Ischaemia, Reperfusion and Angiogenesis

Full Ph.D. program title: 
Injury due to insufficient perfusion and/or due to reperfusion of a previously ischaemic tissue (ischaemia-reperfusion injury) is the underlying cause or decisively involved in many diseases including heart attack, stroke or various kinds of shock.
Faculty: 
Medical Faculty
Graduate School of Biomedical Science (BIOME)
Affiliation: 
University Hospital Essen
Description: 

Lecture and research topics of the 3-year curriculum: Injury due to insufficient perfusion and/or due to reperfusion of a previously ischaemic tissue (ischaemia-reperfusion injury) is the underlying cause or decisively involved in many diseases including heart attack, stroke or various kinds of shock. Ischaemia-reperfusion injury is central to two of the core areas of the Faculty of Medicine, the cardiovascular system and transplantation, but is also related to the other research focus, oncology.

The course does not only cover mechanisms and consequences of cell and tissue injury during ischaemia-reperfusion of various organs including heart, brain, intestine, liver, and muscle but also regenerating processes following ischaemia-reperfusion such as angiogenesis, and protective/therapeutic measures such as pre- and postconditioning and pharmacological treatment. Lectures and seminars are held on the mechanisms of apoptotic and necrotic cell death, signal transduction cascades, inflammatory responses, growth factors, local progenitor and stem cells, and on strategies used to prevent cell and tissue injury induced by ischaemia-reperfusion in different organs and to support regeneration.

Members of the course are given the opportunity to obtain insights into subcellular (mitochondrial), cellular and small/large animal models of ischaemia-reperfusion injury and to get into contact with clinical and translational research on the subject. A wide analytical spectrum is presented including e.g. cell and molecular biology (analysis of cellular dedifferentiation and transcriptional and post-transcriptional regulation), conventional histology, immune staining (immunofluorescence), electron microscopy, confocal 3D imaging, protein-protein interaction analysis, angiogenesis assays, and in vivo imaging.