PD Dr. Alexandra Gellhaus

Research interests: 
  • Human placenta: Molecular mechanisms in pre-eclampsia
  • Mouse placenta: Trophoblast differentiation
  • Placental tumor: Gap junction mediated growth control of choriocarcinoma
  • Endometrium: Gene regulation and feto-maternal interaction
  • Ovary
  • Effects of strong magnetic fields (MRI) on reproduction
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CoLab Biomed research keywords: 
Selected publications: 

Wagener J, Yang W, Kazuschke K, Winterhager E, Gellhaus A. CCN3 regulates proliferation and migration properties in Jeg3 trophoblast cells via ERK1/2, Akt and Notch signalling. Mol Hum Reprod. 2013 Apr;19(4):237-49.

Winterhager E, Gellhaus A, Blois SM, Hill LA, Barr KJ, Kidder GM. Decidual Angiogenesis and Placental Orientation Are Altered in Mice Heterozygous for a Dominant Loss-of-Function Gja1 (Connexin43) Mutation. Biol Reprod. 2013 Sep 18. [Epub ahead of print]

Bendix I, Schulze C, Haefen Cv, Gellhaus A, Endesfelder S, Heumann R, Felderhoff-Mueser U, Sifringer M. Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity. Int J Mol Sci. 2012 Oct 10;13(10):12939-51.

Greif K, Beverung W, Langner F, Frankenberg D, Gellhaus A, Banaz-Yasar F. The PTB microbeam: a versatile instrument for radiobiological research. Radiat Prot Dosimetry. 2006;122(1-4):313-5.  Review.

Mikat B, Gellhaus A, Wagner N, Birdir C, Kimmig R, Köninger A. Early detection of maternal risk for preeclampsia. ISRN Obstet Gynecol. 2012;2012:172808.

Koch Y, van Fürden B, Kaiser S, Klein D, Kibschull M, Schorle H, Carpinteiro A, Gellhaus A, Winterhager E. Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing. Biol Reprod. 2012 Aug 23;87(2):37.

Dunk CE, Gellhaus A, Drewlo S, Baczyk D, Pötgens AJ, Winterhager E, Kingdom JC, Lye SJ. The molecular role of connexin 43 in human trophoblast cell fusion. Biol Reprod. 2012 Apr 19;86(4):115.

Dicke N, Pielensticker N, Degen J, Hecker J, Tress O, Bald T, Gellhaus A, Winterhager E, Willecke K. Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2). J Cell Sci. 2011 Aug 15;124(Pt 16):2806-15.

Yang W, Wagener J, Wolf N, Schmidt M, Kimmig R, Winterhager E, Gellhaus A. Impact of CCN3 (NOV) glycosylation on migration/invasion properties and cell growth of the choriocarcinoma cell line Jeg3. Hum Reprod. 2011 Oct;26(10):2850-60.

Medical Faculty
Graduate School of Biomedical Science (BIOME)
University Hospital Essen
Contact information: 

+49 201 723 1638
University Hospital Essen
Hufelandstr. 55
45147 Essen