Dr. Christine Beuck

Research interests: 
Spectroscopic methods for ligand optimization (STD), epitope identification (chemical shift perturbation) and structural characterization of protein-ligand complexes. 
CoLab Biomed research keywords: 
Selected publications: 

Beuck C, Qu S, Fagg WS, Ares M Jr, Williamson JR. Structural analysis of the quaking homodimerization interface. J Mol Biol. 2012 Nov 9;423(5):766-81.

Beuck C, Szymczyna BR, Kerkow DE, Carmel AB, Columbus L, Stanfield RL, Williamson JR. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation. Structure. 2010 Mar 10;18(3):377-89.

Repges R, Beuck C, Weinhold E, Raabe G, Fleischhauer J. 6-Thioguanine in DNA as CD-spectroscopic probe to study local structural changes upon protein binding. Chirality. 2008 Sep;20(9):978-84.

David A, Bleimling N, Beuck C, Lehn JM, Weinhold E, Teulade-Fichou MP. DNA mismatch-specific base flipping by a bisacridine macrocycle. Chembiochem. 2003 Dec 5;4(12):1326-31.

Beuck C, Singh I, Bhattacharya A, Hecker W, Parmar VS, Seitz O, Weinhold E. Polycyclic aromatic DNA-base surrogates: high-affinity binding to an adenine-specific base-flipping DNA methyltransferase. Angew Chem Int Ed Engl. 2003 Aug 25;42(33):3958-60.

Beuck C, Weinhold E. Convenient synthesis of oligodeoxynucleotides containing 2'-deoxy-6-thioinosine. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):635-9. PubMed PMID: 14565242.

Faculty of Biology
Centre for Medical Biotechnology (ZMB)
University of Duisburg-Essen
Contact information: 

+49 201 183 2929

S03 S00 A35