Dr. Farnusch Kaschani

Research interests: 
  • Chemical Proteomics
Selected publications: 

Villamor JG, Kaschani F, Colby T, Oeljeklaus J, Zhao D, Kaiser M, Patricelli MP, van der Hoorn RA. Profiling protein kinases and other ATP bindingproteins in Arabidopsis using acyl-ATP probes. Mol Cell Proteomics. 2013 May 29. [Epub ahead of print].

Misas-Villamil JC, Kolodziejek I, Crabill E, Kaschani F, Niessen S, Shindo T, Kaiser M, Alfano JR, van der Hoorn RA. Pseudomonas syringae pv. syringae uses proteasome inhibitor syringolin A to colonize from wound infection sites. PLoS Pathog. 2013 Mar;9(3):e1003281.

Lu H, Wang Z, Shabab M, Oeljeklaus J, Verhelst SH, Kaschani F, Kaiser M, Bogyo M, van der Hoorn RA. A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB. Chem Biol. 2013 Feb 21;20(2):168-76.

Misas-Villamil JC, Toenges G, Kolodziejek I, Sadaghiani AM, Kaschani F, Colby T, Bogyo M, van der Hoorn RA. Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection. Plant J. 2013 Feb;73(4):689-700.

Oeljeklaus J, Kaschani F, Kaiser M. Streamlining chemical probe discovery: libraries of "fully functionalized" small molecules for phenotypic screening. Angew Chem Int Ed Engl. 2013 Jan 28;52(5):1368-70.

Stolze SC, Deu E, Kaschani F, Li N, Florea BI, Richau KH, Colby T, van der Hoorn RA, Overkleeft HS, Bogyo M, Kaiser M. The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains. Chem Biol. 2012 Dec 21;19(12):1546-55.

Kaschani F, Clerc J, Krahn D, Bier D, Hong TN, Ottmann C, Niessen S, Colby T, van der Hoorn RA, Kaiser M. Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenases. Angew Chem Int Ed Engl. 2012 May 21;51(21):5230-3.

Richau KH, Kaschani F, Verdoes M, Pansuriya TC, Niessen S, Stüber K, Colby T, Overkleeft HS, Bogyo M, Van der Hoorn RA. Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics. Plant Physiol. 2012 Apr;158(4):1583-99.

van der Linde K, Hemetsberger C, Kastner C, Kaschani F, van der Hoorn RA, Kumlehn J, Doehlemann G. A maize cystatin suppresses host immunity by inhibiting apoplastic cysteine proteases. Plant Cell. 2012 Mar;24(3):1285-300.

Lenger J, Kaschani F, Lenz T, Dalhoff C, Villamor JG, Köster H, Sewald N, van der Hoorn RA. Labeling and enrichment of Arabidopsis thaliana matrix metalloproteases using an active-site directed, marimastat-based photoreactive probe. Bioorg Med Chem. 2012 Jan 15;20(2):592-6.

Kaschani F, Nickel S, Pandey B, Cravatt BF, Kaiser M, van der Hoorn RA. Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP. Bioorg Med Chem. 2012 Jan 15;20(2):597-600.

Nickel S, Kaschani F, Colby T, van der Hoorn RA, Kaiser M. A para-nitrophenol phosphonate probe labels distinct serine hydrolases of Arabidopsis. Bioorg Med Chem. 2012 Jan 15;20(2):601-6.

Kaschani F, Gu C, van der Hoorn RA. Activity-based protein profiling of infected plants. Methods Mol Biol. 2012;835:47-59. Gu C, Shabab M, Strasser R, Wolters PJ, Shindo T, Niemer M, Kaschani F, Mach L, van der Hoorn RA. Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana. PLoS One. 2012;7(3):e32422.

Kolodziejek I, Misas-Villamil JC, Kaschani F, Clerc J, Gu C, Krahn D, Niessen S, Verdoes M, Willems LI, Overkleeft HS, Kaiser M, van der Hoorn RA. Proteasome activity imaging and profiling characterizes bacterial effector syringolin A. Plant Physiol. 2011 Jan;155(1):477-89.

Kaschani F, Van der Hoorn RA. A model of the C14-EPIC complex indicates hotspots for a protease-inhibitor arms race in the oomycete-potato interaction. Plant Signal Behav. 2011 Jan;6(1):109-12.

Kaschani F, Shabab M, Bozkurt T, Shindo T, Schornack S, Gu C, Ilyas M, Win J, Kamoun S, van der Hoorn RA. An effector-targeted protease contributes to defense against Phytophthora infestans and is under diversifying selection in natural hosts. Plant Physiol. 2010 Dec;154(4):1794-804.

Kaschani F, Gu C, Niessen S, Hoover H, Cravatt BF, van der Hoorn RA. Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana. Mol Cell Proteomics. 2009 May;8(5):1082-93.

Song J, Win J, Tian M, Schornack S, Kaschani F, Ilyas M, van der Hoorn RA,Kamoun S. Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1654-9.

Kaschani F, Verhelst SH, van Swieten PF, Verdoes M, Wong CS, Wang Z, Kaiser M, Overkleeft HS, Bogyo M, van der Hoorn RA. Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using'click chemistry'. Plant J. 2009 Jan;57(2):373-85.

Shabab M, Shindo T, Gu C, Kaschani F, Pansuriya T, Chintha R, Harzen A, Colby T, Kamoun S, van der Hoorn RA. Fungal effector protein AVR2 targets diversifying defense-related cys proteases of tomato. Plant Cell. 2008 Apr;20(4):1169-83.

Kaschani F, van der Hoorn R. Small molecule approaches in plants. Curr Opin Chem Biol. 2007 Feb;11(1):88-98. Epub 2007 Jan 5. Review.

Research group: 
Faculty of Biology
Centre for Medical Biotechnology (ZMB)
University of Duisburg-Essen
Contact information: 

Phone 
+49 201 183 4982

Location 
Campus Essen
Room S03 S02 A62