Prof. Dr. Herbert de Groot

Research interests: 

Free Radicals

  • Cell and tissue injury by "free radicals" (reactive oxygen and nitrogen species) such as hydrogen peroxide (H2O2), nitrogen monoxide (NO), superoxide (O-2), and peroxynitrite (ONOO-)
  • Contribution of transition metal ions (iron and copper)
  • Necrotic vs. apoptotic forms of cell death
  • Reaction of free radicals with essential cellular components
  • Artificial enzymes as catalase-like antioxidants
  • Transformed cells with variable superoxide dismutase activity
  • Protective effect of the oncogene Bcl-2

Hypoxia (Oxygen Deficiency)

  • Role of sodium and calcium homeostasis in hypoxic cell injury
  • Studies at the single cell level using digital fluorecence microscopy
  • Testing of protective substances
  • Studies with the isolated perfused liver


  • Cold-induced apoptosis
  • Studies on specific hypothermia-induced mechanisms of cell injury
  • New options for the storage of isolated cells
  • Studies on cell injury under the conditions of organ preservation
  • Improvement of preservation solutions
CoLab Biomed research keywords: 
Research group: 
Medical Faculty
Graduate School of Biomedical Science (BIOME)
Centre for Medical Biotechnology (ZMB)
University of Duisburg-Essen
University Hospital Essen
Contact information: 

Jacqueline Arnold-Thomas
+49 201 723 4101
Virchowstra├če 171
University Hospital Essen
IG I, 4. OG, Area C, Room 3