Prof. Dr. Joachim Fandrey

Research interests: 

Oxygen-dependent Gene Expression

  • Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1).

Mechanisms of Inflammatory Reactions Role of HIF-1 Complexes

  • Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules 
  • Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors 
  • Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability
  • Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases.

Role of HIF-1 Complexes in Muscle Trauma

  • Activation of HIF-1 in traumatized tissue 
  • Role of HIF-1 activation for the severity of tissue trauma
  • Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle
Research group: 
Medical Faculty
Centre for Medical Biotechnology (ZMB)
University Hospital Essen
Contact information: 

Ute Häusler
Phone:
+49201 723 4601
Location:
Institutsgruppe I, Virchowstr. 171
Address:
Hufelandstrasse 55
D-45147 Essen