Dr. Joachim Göthert

Research interests: 
  • Stem cell research
  • Leukemogenesis
  • Haematopoietic transcription
CoLab Biomed research keywords: 
Selected publications: 

Göthert JR, Eisele L, Klein-Hitpass L, Weber S, Zesewitz ML, Sellmann L, Röth A, Pircher H, Dührsen U, Dürig J. Expanded CD8(+) T cells of murine and human CLL are driven into a senescent KLRG1(+) effector memory phenotype. Cancer Immunol Immunother. 2013 Sep 11. [Epub ahead of print]

Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E. Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. J Immunol. 2013 Jun 1;190(11):5676-88.

Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Häussinger D, Lee KH, Mak TW. Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2593-8.

Retailleau K, Toutain B, Galmiche G, Fassot C, Sharif-Naeini R, Kauffenstein G, Mericskay M, Duprat F, Grimaud L, Merot J, Lardeux A, Pizard A, Baudrie V, Jeunemaitre X, Feil R, Göthert JR, Lacolley P, Henrion D, Li Z, Loufrani L. Selective involvement of serum response factor in pressure-induced myogenic tone in resistance arteries. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):339-46.

Sprüssel A, Schulte JH, Weber S, Necke M, Händschke K, Thor T, Pajtler KW, Schramm A, König K, Diehl L, Mestdagh P, Vandesompele J, Speleman F, Jastrow H, Heukamp LC, Schüle R, Dührsen U, Buettner R, Eggert A, Göthert JR. Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation. Leukemia. 2012 Sep;26(9):2039-51.

Courtial N, Smink JJ, Kuvardina ON, Leutz A, Göthert JR, Lausen J. Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP. FASEB J. 2012 Feb;26(2):523-32.

Meyer zu Hörste M, Ströher E, Berchner-Pfannschmidt U, Schmitz-Spanke S, Pink M, Göthert JR, Fischer JW, Gulbins E, Eckstein AK. A novel mechanism involved in the pathogenesis of Graves ophthalmopathy (GO): clathrin is a possible targeting molecule for inhibiting local immune response in the orbit. J Clin Endocrinol Metab. 2011 Nov;96(11):E1727-36.

Aydin S, Grabellus F, Eisele L, Möllmann M, Hanoun M, Ebeling P, Moritz T, Carpinteiro A, Nückel H, Sak A, Göthert JR, Dührsen U, Dürig J. Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model. Eur J Haematol. 2011 Jul;87(1):10-9.

Schemionek M, Elling C, Steidl U, Bäumer N, Hamilton A, Spieker T, Göthert JR, Stehling M, Wagers A, Huettner CS, Tenen DG, Tickenbrock L, Berdel WE, Serve H, Holyoake TL, Müller-Tidow C, Koschmieder S. BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood. 2010 Apr 22;115(16):3185-95.

Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol. 2008 Apr 7;181(1):43-50.

Acevedo LM, Barillas S, Weis SM, Göthert JR, Cheresh DA. Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood. 2008 Mar 1;111(5):2674-80.

Göthert JR, Brake RL, Smeets M, Dührsen U, Begley CG, Izon DJ. NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis. Blood. 2007 Nov 15;110(10):3753-62.

Bradley CK, Takano EA, Göthert JR, Göttgens B, Green AR, Begley CG, van Eekelen JA. Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system. Genesis. 2007 Mar;45(3):145-51.

Bradley CK, Takano EA, Hall MA, Göthert JR, Harvey AR, Begley CG, van Eekelen JA. The essential haematopoietic transcription factor Scl is also critical for neuronal development. Eur J Neurosci. 2006 Apr;23(7):1677-89.

Göthert JR, Gustin SE, Hall MA, Green AR, Göttgens B, Izon DJ, Begley CG. In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood. 2005 Apr 1;105(7):2724-32.

Göthert JR, Gustin SE, van Eekelen JA, Schmidt U, Hall MA, Jane SM, Green AR, Göttgens B, Izon DJ, Begley CG. Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood. 2004 Sep 15;104(6):1769-77.

Göttgens B, Broccardo C, Sanchez MJ, Deveaux S, Murphy G, Göthert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, Barton LM, Knezevic K, Erber WN, Begley CG, Frampton J, Green AR. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol. 2004 Mar;24(5):1870-83.

van Eekelen JA, Bradley CK, Göthert JR, Robb L, Elefanty AG, Begley CG, Harvey AR. Expression pattern of the stem cell leukaemia gene in the CNS of the embryonic and adult mouse. Neuroscience. 2003;122(2):421-36.

Hall MA, Curtis DJ, Metcalf D, Elefanty AG, Sourris K, Robb L, Gothert JR, Jane SM, Begley CG. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):992-7.

Research group: 
Medical Faculty
Graduate School of Biomedical Science (BIOME)
West German Cancer Center (WTZ)
University of Duisburg-Essen
University Hospital Essen