Dr. Manuela Wülling

Research interests: 
  • Bone development
  • Chondrocyte differentiation
  • Bone diseases
CoLab Biomed research keywords: 
Selected publications: 

Wuelling M, Vortkamp A. Cartilage explant cultures. Methods Mol Biol. 2014;1130:89-97

Dittmann K, Wuelling M, Uhmann A, Dullin C, Hahn H, Schweyer S, Vortkamp A, Wienands J. Inactivation of Patched 1 in chondrocytes causes spinal fusion without inflammation. Arthritis Rheum. 2013 Dec 24.

Wuelling M, Pasdziernik M, Moll CN, Thiesen AM, Schneider S, Johannes C, Vortkamp A. The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis. Cell Cycle. 2013 Jul 15;12(14):2219-32.

Wuelling M, Pasdziernik M, Moll CN, Thiesen AM, Schneider S, Johannes C, Vortkamp A. The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis. Cell Cycle. 2013 Jun 20;12(14).

Ehlen HW, Chinenkova M, Moser M, Munter HM, Krause Y, Gross S, Brachvogel B, Wuelling M, Kornak U, Vortkamp A. Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res. 2013 Feb;28(2):246-59.

Gross S, Krause Y, Wuelling M, Vortkamp A. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One. 2012;7(8):e43553.

Galli GG, Honnens de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, Multhaupt HA, Fog CK, Jensen KT, Rappsilber J, Vortkamp A, Coulton L, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Calogero RA, Couchman JR, Lund AH. Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone. PLoS Genet. 2012;8(5):e1002711.

Wuelling M, Vortkamp A. Chondrocyte proliferation and differentiation. Endocr Dev. 2011;21:1-11.

Friedrichs M, Wirsdöerfer F, Flohé SB, Schneider S, Wuelling M, Vortkamp A. BMP signaling balances proliferation and differentiation of muscle satellite cell descendants. BMC Cell Biol. 2011 Jun 6;12:26.

Detsch R, Hagmeyer D, Neumann M, Schaefer S, Vortkamp A, Wuelling M, Ziegler G, Epple M. The resorption of nanocrystalline calcium phosphates by osteoclast-like cells. Acta Biomater. 2010 Aug;6(8):3223-33.

Wuelling M, Vortkamp A. Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification. Pediatr Nephrol. 2010 Apr;25(4):625-31.

Wuelling M, Kaiser FJ, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A. Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009 Apr 1;328(1):40-53.

Kantaputra P, Miletich I, Lüdecke HJ, Suzuki EY, Praphanphoj V, Shivdasani R, Wuelling M, Vortkamp A, Napierala D, Sharpe PT. Tricho-rhino-phalangeal syndrome with supernumerary teeth. J Dent Res. 2008 Nov;87(11):1027-31.

Jahnke P, Xu W, Wülling M, Albrecht M, Gabriel H, Gillessen-Kaesbach G, Kaiser FJ. The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications. Nucleic Acids Res. 2008 Nov;36(20):6450-8.

Tagariello A, Luther J, Streiter M, Didt-Koziel L, Wuelling M, Surmann-Schmitt C, Stock M, Adam N, Vortkamp A, Winterpacht A. Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes. Matrix Biol. 2008 Jan;27(1):3-11.

Koziel L, Wuelling M, Schneider S, Vortkamp A. Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development. 2005 Dec;132(23):5249-60.

Wuelling M, Delling G, Kaiser E. Differential gene expression in stromal cells of human giant cell tumor of bone. Virchows Arch. 2004 Dec;445(6):621-30.

Wuelling M, Engels C, Jesse N, Werner M, Kaiser E, Delling G. [Histogenesis of giant cell tumors]. Pathologe. 2002 Sep;23(5):332-9. Review. German.

Research group: 
Faculty of Biology
Centre for Medical Biotechnology (ZMB)
University of Duisburg-Essen
Contact information: 
Phone
+49 201 183 3646
Room
S03 S01 A59
 
Campus Essen