Dr. Wibke Bayer

Research interests: 
  • Basic cellular and molecular mechanisms of immunity against retroviruses
  • Vaccine development against retroviruses
  • Immunotherapy against retroviral infections and virus-induced cancer
  • Persistent viral infections
  • Retrovirus-induced immunosuppression
CoLab Biomed research keywords: 
Selected publications: 

Ohs I, Windmann S, Wildner O, Dittmer U, Bayer W. Interleukin-Encoding Adenoviral Vectors as Genetic Adjuvant for Vaccination against Retroviral Infection. PLoS One. 2013 Dec 4;8(12):e82528.

Gödel P, Windmann S, Dietze KK, Dittmer U, Bayer W. Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization. J Virol. 2012 Nov;86(22):12422-5.

Lietz R, Bayer W, Ontikatze T, Johrden L, Tenbusch M, Storcksdieck Genannt Bonsmann M, Uberla K, Dittmer U, Wildner O. Codelivery of the chemokine CCL3 by an adenovirus-based vaccine improves protection from retrovirus infection. J  Virol. 2012 Feb;86(3):1706-16.

Nair S, Bayer W, Ploquin MJ, Kassiotis G, Hasenkrug KJ, Dittmer U. Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model. Retrovirology. 2011 Sep 26;8:76.

Bayer W, Lietz R, Ontikatze T, Johrden L, Tenbusch M, Nabi G, Schimmer S, Groitl P, Wolf H, Berry CM, Uberla K, Dittmer U, Wildner O. Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes. Retrovirology. 2011 Sep 26;8:75.

Bayer W, Tenbusch M, Lietz R, Johrden L, Schimmer S, Uberla K, Dittmer U, Wildner O. Vaccination with an adenoviral vector that encodes and displays a retroviral antigen induces improved neutralizing antibody and CD4+ T-cell responses and confers enhanced protection. J Virol. 2010 Feb;84(4):1967-76.

Bayer W, Schimmer S, Hoffmann D, Dittmer U, Wildner O. Evaluation of the Friend Virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies. Vaccine. 2008 Jan 30;26(5):716-26.

Hoffmann D, Bayer W, Wildner O. Therapeutic immune response induced by intratumoral expression of the fusogenic membrane protein of vesicular stomatitis virus and cytokines encoded by adenoviral vectors. Int J Mol Med. 2007 Nov;20(5):673-81.

Hoffmann D, Bayer W, Wildner O. In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines. World J Gastroenterol. 2007 Jun 14;13(22):3063-70.

Hoffmann D, Bayer W, Wildner O. Local and distant immune-mediated control of colon cancer growth with fusogenic membrane glycoproteins in combination with viral oncolysis. Hum Gene Ther. 2007 May;18(5):435-50.

Email address: 
Research group: 
Medical Faculty
Graduate School of Biomedical Science (BIOME)
University Hospital Essen
Contact information: 

+49 201 723 83034
Virchowstr. 179
D-45147 Essen